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G6PC antibody (N-Term)

G6PC Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2781770
  • Target See all G6PC Antibodies
    G6PC (Glucose 6-Phosphatase, Catalytic (G6PC))
    Binding Specificity
    • 7
    • 6
    • 6
    • 6
    • 5
    • 1
    N-Term
    Reactivity
    • 37
    • 18
    • 17
    • 15
    • 14
    • 13
    • 1
    • 1
    • 1
    Human
    Host
    • 37
    • 1
    Rabbit
    Clonality
    • 37
    • 1
    Polyclonal
    Conjugate
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This G6PC antibody is un-conjugated
    Application
    • 29
    • 19
    • 14
    • 11
    • 11
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    NLVFKWILFG QRPYWWVLDT DYYSNTSVPL IKQFPVTCET GPGSPSGHAM
    Predicted Reactivity
    Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%, Sheep: 100%
    Characteristics
    This is a rabbit polyclonal antibody against G6PC. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human G6PC
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 357 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and may contain up to 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Iwasa, Kobayashi, Mifuji-Moroka, Hara, Miyachi, Sugimoto, Tanaka, Fujita, Gabazza, Takei: "Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis." in: PLoS ONE, Vol. 8, Issue 7, pp. e70309, (2013) (PubMed).

  • Target
    G6PC (Glucose 6-Phosphatase, Catalytic (G6PC))
    Alternative Name
    G6PC (G6PC Products)
    Synonyms
    AW107337 antibody, G6Pase antibody, G6pt antibody, Glc-6-Pase antibody, G6PC1 antibody, G6PT antibody, GSD1 antibody, GSD1a antibody, G-6-Pase antibody, glucose-6-phosphatase, catalytic antibody, glucose-6-phosphatase catalytic subunit antibody, glucose-6-phosphatase, catalytic subunit antibody, G6pc antibody, G6PC antibody
    Background
    G6PC hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum.It forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: G6PT, GSD1a, MGC163350, GSD1, G6PC1
    Protein Interaction Partner: NSL1, SNX13, CDH16, FOXO1,
    Protein Size: 357
    Molecular Weight
    40 kDa
    Gene ID
    2538
    NCBI Accession
    NM_000151, NP_000142
    UniProt
    P35575
    Pathways
    Carbohydrate Homeostasis, Cellular Glucan Metabolic Process
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