LRP8 antibody (Middle Region)

Catalog No. ABIN2781811

Product Details anti-LRP8 Antibody

Target: LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow, Sheep, Zebrafish (Danio rerio), Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NRKMLIFSTD FLSHPFGVAV FEDKVFWTDL ENEAIFSANR LNGLEIAILA

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 92%, Sheep: 93%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against Lrp8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 996 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for LRP8

Target: LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))

Alternative Name: Lrp8 (LRP8 Products)

Synonyms: LRP8 antibody, APOER2 antibody, HSZ75190 antibody, LRP-8 antibody, MCI1 antibody, 4932703M08Rik antibody, AA921429 antibody, AI848122 antibody, ApoER2 antibody, Lr8b antibody, LR8B antibody, LDL receptor related protein 8 antibody, low density lipoprotein receptor-related protein 8, apolipoprotein e receptor antibody, LRP8 antibody, Lrp8 antibody

Background: Lrp8 is the cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Lrp8 binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Lrp8 is highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. Lrp8 may also function as an endocytic receptor.
Alias Symbols: 4932703M08Rik, AA921429, AI848122, Lr8b, apoER2, ApoER2
Protein Interaction Partner: Dab1, Mapk8ip1, Mapk8ip2, Snx17,
Protein Size: 996

Molecular Weight: 110 kDa

Gene ID: 16975

NCBI Accession: NM_053073, NP_444303

UniProt: Q924X6