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HGF antibody (N-Term)

HGF Reactivity: Human, Rat, Mouse, Dog, Sheep, Rabbit, Cow, Horse, Guinea Pig, Pig, Zebrafish (Danio rerio) WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2781816
  • Target See all HGF Antibodies
    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
    Binding Specificity
    • 16
    • 15
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 81
    • 32
    • 31
    • 15
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Dog, Sheep, Rabbit, Cow, Horse, Guinea Pig, Pig, Zebrafish (Danio rerio)
    Host
    • 70
    • 22
    • 4
    • 1
    Rabbit
    Clonality
    • 76
    • 21
    Polyclonal
    Conjugate
    • 47
    • 14
    • 10
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HGF antibody is un-conjugated
    Application
    • 88
    • 37
    • 30
    • 14
    • 13
    • 13
    • 12
    • 12
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    VKKEFGHEFD LYENKDYIRN CIIGKGRSYK GTVSITKSGI KCQPWSSMIP
    Specificity
    100 % homologous to all 6 isoforms, 1 (83 kDa), 2 (34 kDa), 3 (83 kDa), 4 (35 kDa), 5 (33 kDa), 6 (24 kDa)
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 80%
    Characteristics
    This is a rabbit polyclonal antibody against HGF. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human HGF
    Top Product
    Discover our top product HGF Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 728 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and may contain up to 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Nejak-Bowen, Orr, Bowen, Michalopoulos: "Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy." in: PLoS ONE, Vol. 8, Issue 3, pp. e59836, (2013) (PubMed).

    Ji, Zhang, You, Li, Liu, Jiang, Liu, Zhang, Wang, Tao, Dou: "The differentiation of MSCs into functional hepatocyte-like cells in a liver biomatrix scaffold and their transplantation into liver-fibrotic mice." in: Biomaterials, Vol. 33, Issue 35, pp. 8995-9008, (2012) (PubMed).

    Zampell, Avraham, Yoder, Fort, Yan, Weitman, Mehrara: "Lymphatic function is regulated by a coordinated expression of lymphangiogenic and anti-lymphangiogenic cytokines." in: American journal of physiology. Cell physiology, Vol. 302, Issue 2, pp. C392-404, (2012) (PubMed).

    Sen, Peng, Saigal, Williams, Johnson: "Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 3, pp. 514-24, (2011) (PubMed).

    Williams, Mehta, Peyton, Zeiger, Van Vliet, Griffith: "Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays." in: Tissue engineering. Part A, Vol. 17, Issue 7-8, pp. 1055-68, (2011) (PubMed).

  • Target
    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
    Alternative Name
    HGF (HGF Products)
    Synonyms
    DFNB39 antibody, F-TCF antibody, HGFB antibody, HPTA antibody, SF antibody, HGF antibody, C230052L06Rik antibody, HGF/SF antibody, NK1 antibody, NK2 antibody, SF/HGF antibody, hepatocyte growth factor antibody, HGF antibody, Hgf antibody
    Background
    Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69- kDa alpha-chain and 34- kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity.Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69- kDa alpha-chain and 34- kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
    Alias Symbols: F-TCF, HGFB, HPTA, SF, DFNB39
    Protein Interaction Partner: ADAMTSL4, MEOX2, MET, F11, ST14, HGFAC, LCN2, KLKB1, VTN, PLAU, CLEC3B, SDC1, SDC2, HPN, HGF, FN1, NRP1,
    Protein Size: 728
    Molecular Weight
    83 kDa
    Gene ID
    3082
    NCBI Accession
    NM_001010932, NP_001010932
    UniProt
    P14210
    Pathways
    RTK Signaling, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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