GGCX antibody (Middle Region)

Catalog No. ABIN2781826

Product Details anti-GGCX Antibody

Target: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GGCX antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: FLLRKLYVFR RSFLMTCISL RNLILGRPSL EQLAQEVTYA NLRPFEAVGE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against GGCX. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GGCX

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 758 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GGCX

Target: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Alternative Name: GGCX (GGCX Products)

Synonyms: GGCX antibody, cb751 antibody, si:ch1073-230p18.3 antibody, zgc:158736 antibody, ggcx antibody, GGC antibody, vkcfd1 antibody, CG13927 antibody, DgammaC antibody, Dmel\\CG13927 antibody, dGC antibody, dgammaC antibody, gammaC antibody, VKCFD1 antibody, gamma-glutamyl carboxylase antibody, gamma-glutamyl carboxylase L homeolog antibody, GGCX antibody, ggcx antibody, GC antibody, sce5891 antibody, ggcx.L antibody, Ggcx antibody

Background: GGCX is an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency.Gamma-glutamyl carboxylase accomplishes the posttranslational modification required for the activity of all of the vitamin K-dependent proteins (Wu et al., 1991 [PubMed 1749935]). These include some of the blood coagulation and anticoagulation proteins as well as bone gamma-carboxyglutamic acid (Gla) protein (BGLAP, MIM 112260) and bone matrix protein (MGP, MIM 154870).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ26629, VKCFD1
Protein Interaction Partner: UBC, DCP2, FBXO6, F9, F10, F7, F2, PROC, BGLAP,
Protein Size: 758

Molecular Weight: 87 kDa

Gene ID: 2677

NCBI Accession: NM_000821, NP_000812

UniProt: P38435

Pathways: SARS-CoV-2 Protein Interactome