PTGIS antibody (Middle Region)

Catalog No. ABIN2781839

Product Details anti-PTGIS Antibody

Target: PTGIS (Prostaglandin I2 (Prostacyclin) Synthase (PTGIS))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Dog, Zebrafish (Danio rerio), Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTGIS antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EIYTDPEVFK YNRFLNPDGS EKKDFYKDGK RLKNYNMPWG AGHNHCLGRS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against PTGIS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PTGIS

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 500 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PTGIS

Target: PTGIS (Prostaglandin I2 (Prostacyclin) Synthase (PTGIS))

Alternative Name: PTGIS (PTGIS Products)

Synonyms: CYP8 antibody, CYP8A1 antibody, PGIS antibody, PTGI antibody, Cyp8 antibody, Cyp8a1 antibody, Pgis antibody, ptgisl antibody, PTGIS antibody, prostaglandin I2 synthase antibody, prostaglandin I2 (prostacyclin) synthase antibody, prostacyclin synthase antibody, PTGIS antibody, Ptgis antibody, ptgis antibody, VDBG_06319 antibody

Background: PTGIS is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CYP8, CYP8A1, MGC126858, MGC126860, PGIS, PTGI
Protein Interaction Partner: CAV1, PTGS2, PTGS1, APP,
Protein Size: 500

Molecular Weight: 57 kDa

Gene ID: 5740

NCBI Accession: NM_000961, NP_000952

UniProt: Q16647