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ACVR2B antibody (C-Term)

ACVR2B Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, Guinea Pig, Zebrafish (Danio rerio), Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2782112
  • Target See all ACVR2B Antibodies
    ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
    Binding Specificity
    • 15
    • 9
    • 9
    • 7
    • 7
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 76
    • 30
    • 30
    • 10
    • 9
    • 7
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Dog, Cow, Horse, Sheep, Guinea Pig, Zebrafish (Danio rerio), Rabbit
    Host
    • 74
    • 7
    • 3
    Rabbit
    Clonality
    • 79
    • 5
    Polyclonal
    Conjugate
    • 37
    • 13
    • 5
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ACVR2B antibody is un-conjugated
    Application
    • 79
    • 28
    • 27
    • 13
    • 13
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    HDAEARLSAG CVEERVSLIR RSVNGTTSDC LVSLVTSVTN VDLPPKESSI
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 100%, Sheep: 100%, Zebrafish: 93%
    Characteristics
    This is a rabbit polyclonal antibody against ACVR2B. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human ACVR2B
    Top Product
    Discover our top product ACVR2B Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 303 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
    Alternative Name
    ACVR2B (ACVR2B Products)
    Synonyms
    ACVR2B antibody, XAR1 antibody, actr-iib antibody, actriib antibody, ACTRIIB antibody, ActR-IIB antibody, HTX4 antibody, ActRIIB antibody, actr2b antibody, actrIIb antibody, wu:fj97d11 antibody, activin A receptor type 2B antibody, activin A receptor type 2B L homeolog antibody, activin A receptor type 2Ba antibody, activin receptor IIB antibody, ACVR2B antibody, acvr2b antibody, acvr2b.L antibody, Acvr2b antibody, acvr2ba antibody
    Background
    Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B is activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
    Alias Symbols: HTX4, ACTRIIB, ActR-IIB
    Protein Interaction Partner: GDF2, BMP10, INHBA, PEG10, ERBB2IP, HSP90AA1, SMAD7, SMAD6, SMAD2, IGSF1, SYNJ2BP, SNX6, SNX2, TGFBRAP1, GDF11, MSTN, ACVR1B, SNX1, INHBC, GDF5, INHBB, BMP7, BMP2, ENG, BMP6,
    Protein Size: 303
    Molecular Weight
    33 kDa
    Gene ID
    93
    NCBI Accession
    NM_001106
    UniProt
    Q13705
    Pathways
    Hormone Transport, Cancer Immune Checkpoints
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