GZMK antibody (Middle Region)
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- Target See all GZMK Antibodies
- GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GZMK antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LRSGTKCKVT GWGATDPDSL RPSDTLREVT VTVLSRKLCN SQSYYNGDPF
- Predicted Reactivity
- Human: 100%, Pig: 93%
- Characteristics
- This is a rabbit polyclonal antibody against GZMK. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human GZMK
- Top Product
- Discover our top product GZMK Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Antigen size: 264 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))
- Alternative Name
- GZMK (GZMK Products)
- Synonyms
- TRYP2 antibody, granzyme K antibody, GZMK antibody, Gzmk antibody
- Background
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GZMK is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TRYP2
Protein Interaction Partner: SET, HMGB2, APEX1, PNKP, LIG4, HNRNPK, GOLGA2, ACTG1, TUBB3, NPLOC4, VCP, UFD1L,
Protein Size: 264 - Molecular Weight
- 26 kDa
- Gene ID
- 3003
- NCBI Accession
- NM_002104, NP_002095
- UniProt
- P49863
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