PTPRN antibody (Middle Region)

Catalog No. ABIN2782197

Product Details anti-PTPRN Antibody

Target: PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Pig, Cow, Rabbit, Guinea Pig, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRN antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EVQQVPSPVS SEPPKAARPP VTPVLLEKKS PLGQSQPTVA GQPSARPAAE

Predicted Reactivity: Cow: 86%, Dog: 100%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 86%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PTPRN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PTPRN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 591 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PTPRN

Target: PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))

Alternative Name: PTPRN (PTPRN Products)

Synonyms: IA-2 antibody, IA-2/PTP antibody, IA2 antibody, ICA512 antibody, R-PTP-N antibody, mIA-A antibody, mKIAA4064 antibody, Ia-2 antibody, fc43c04 antibody, ptprn antibody, wu:fc43c04 antibody, ia-2 antibody, ia2 antibody, ica512 antibody, r-ptp-n antibody, protein tyrosine phosphatase, receptor type N antibody, protein tyrosine phosphatase, receptor type, N antibody, protein tyrosine phosphatase, receptor type, Na antibody, protein tyrosine phosphatase, receptor type N L homeolog antibody, PTPRN antibody, Ptprn antibody, ptprna antibody, ptprn.L antibody

Background: PTPRN is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
Alias Symbols: FLJ16131, IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N
Protein Interaction Partner: PLP1, MAL, CLN8, UBQLN4, SNX19, SPTBN4, PTPRT, MADD, PTPRS, SNTB2, NOS1, PPIA, CAPN2,
Protein Size: 889

Molecular Weight: 96 kDa

Gene ID: 5798

NCBI Accession: NM_001199763

UniProt: Q16849