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Patched 2 antibody (N-Term)

PTCH2 Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2782247
  • Target See all Patched 2 (PTCH2) Antibodies
    Patched 2 (PTCH2)
    Binding Specificity
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 15
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig
    Host
    • 14
    • 1
    Rabbit
    Clonality
    • 14
    • 1
    Polyclonal
    Conjugate
    • 11
    • 2
    • 1
    • 1
    This Patched 2 antibody is un-conjugated
    Application
    • 10
    • 8
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    LAQEALPENA SQQIHAFSST TLDDILHAFS EVSAARVVGG YLLMLAYACV
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against PTCH2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PTCH2
    Top Product
    Discover our top product PTCH2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1203 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Patched 2 (PTCH2)
    Alternative Name
    PTCH2 (PTCH2 Products)
    Synonyms
    PTC2 antibody, ptc2 antibody, Ptch1 antibody, ptc-2 antibody, xptc-2 antibody, xptch-2 antibody, patched-2 antibody, ptch2 antibody, ptc-1 antibody, ptc1 antibody, ptch1 antibody, patched 2 antibody, patched 2 S homeolog antibody, patched 2 L homeolog antibody, PTCH2 antibody, Ptch2 antibody, ptch2.S antibody, ptch2.L antibody, ptch2 antibody
    Background
    PTCH2 is a member of the patched protein family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. The gene encoding PTCH2 is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. This gene encodes a member of the patched gene family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. Alternative transcript variants have been described, but their biological function has not been determined. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-10 AF119569.1 1-10 11-534 AY359016.1 3-526 535-2066 AF087651.1 523-2054 2067-2509 AF119569.1 2067-2509 2510-2520 AF087651.1 2498-2508 2521-2700 AF119569.1 2521-2700 2701-3620 AY358555.1 2689-3608 3621-3624 AF087651.1 3609-3612
    Alias Symbols: PTC2
    Protein Interaction Partner: ARRB1, DHH, SMO, IHH, SHH,
    Protein Size: 1203
    Molecular Weight
    130 kDa
    Gene ID
    8643
    NCBI Accession
    NM_003738, NP_003729
    UniProt
    Q9Y6C5
    Pathways
    Hedgehog Signaling
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