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RRM2B antibody (Middle Region)
RRM2B
Reactivity: Human, Rat, Mouse, Cow, Rabbit, Horse, Pig, Dog, Guinea Pig, Saccharomyces cerevisiae, Zebrafish (Danio rerio)
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-RRM2B Antibody
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Target
See all RRM2B Antibodies
RRM2B
(Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
Binding Specificity
All epitopes for RRM2B antibodies
Middle Region
Reactivity
All reactivities for RRM2B antibodies
Human, Rat, Mouse, Cow, Rabbit, Horse, Pig, Dog, Guinea Pig, Saccharomyces cerevisiae, Zebrafish (Danio rerio)
Host
All hosts for RRM2B antibodies
Rabbit
Clonality
All clonalities for RRM2B antibodies
Polyclonal
Conjugate
All conjugates for RRM2B antibodies
This RRM2B antibody is un-conjugated
Application
All applications for RRM2B antibodies
Western Blotting (WB)
Sequence
VHSEMYSLLI DTYIRDPKKR EFLFNAIETM PYVKKKADWA LRWIADRKST
Predicted Reactivity
Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 100%, Rat: 93%, Yeast: 93%, Zebrafish: 93%
Characteristics
This is a rabbit polyclonal antibody against RRM2B. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human RRM2B
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Discover our top product RRM2B Primary Antibody
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for RRM2B
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Target
RRM2B
(Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
Alternative Name
RRM2B (RRM2B Products )
Background
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described. Protein Interaction Partner: RRM2B, ORC4, UBC, AICDA, RRM1, TP53, RRM2, MDM2, ATM, ZBTB17, MYC, Protein Size: 299
Molecular Weight
32 kDa
Gene ID
50484
Pathways
p53 Signaling , Negative Regulation of intrinsic apoptotic Signaling
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