SKAP1 antibody (N-Term)

Catalog No. ABIN2782452

Product Details anti-SKAP1 Antibody

Target: SKAP1 (Src Kinase Associated phosphoprotein 1 (SKAP1))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SKAP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RDHILRGFQQ IKARYYWDFQ PQGGDIGQDS SDDNHSGTLG LSLTSDAPFL

Predicted Reactivity: Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against SKAP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SKAP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 359 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SKAP1

Target: SKAP1 (Src Kinase Associated phosphoprotein 1 (SKAP1))

Alternative Name: SKAP1 (SKAP1 Products)

Synonyms: 1700091G21Rik antibody, Scap1 antibody, Skap-55 antibody, SCAP1 antibody, SKAP55 antibody, Skap55 antibody, src family associated phosphoprotein 1 antibody, src kinase associated phosphoprotein 1 antibody, Skap1 antibody, SKAP1 antibody

Background: SKAP1 Is a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.
Alias Symbols: SCAP1, SKAP55
Protein Interaction Partner: FAM102A, PRAM1, SH2D4A, BLCAP, APP, LCK, FYN, FYB, SRC, LYN, PTPRC, GRB2, SKAP1,
Protein Size: 359

Molecular Weight: 41 kDa

Gene ID: 8631

NCBI Accession: NM_003726, NP_003717

UniProt: Q86WV1