HIST1H1C antibody (Histone Cluster 1, H1c) (Middle Region)

Details for Product anti-HIST1H1C Antibody No. ABIN2782497, Supplier: Log in to see
Antigen
  • HIST1H1C
  • H1.2
  • H1C
  • H1F2
  • H1s-1
  • 0610008C09Rik
  • H1c
  • H1f2
  • H1var1
  • His1a
  • H14
  • H1d
  • H1f4
  • Hist1h1c
  • Hist1h1e
  • histone cluster 1, H1c
  • histone cluster 1, H1.11L (similar to human histone cluster 1, class H1 genes)
  • histone cluster 1, H1d
  • HIST1H1C
  • HIST1H111L
  • Hist1h1c
  • Hist1h1d
Epitope
Middle Region
11
10
8
7
2
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
37
8
8
Host
Rabbit
37
Clonality
Polyclonal
Conjugate
This HIST1H1C antibody is un-conjugated
2
2
2
2
2
2
Application
Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
34
22
10
4
3
3
2
1
Options
Supplier
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human HIST1H1C
Blocking Peptide Blocking peptide for this product available: ABIN978000
Sequence ASGSFKLNKK AASGEAKPKV KKAGGTKPKK PVGAAKKPKK AAGGATPKKS
Predicted Reactivity Cow: 86%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 85%, Rat: 86%
Characteristics This is a rabbit polyclonal antibody against HIST1H1C. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name HIST1H1C (HIST1H1C Antibody Abstract)
Background Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: H1.2, H1F2, MGC3992, H1C
Protein Interaction Partner: UBC, CEP250, ATRX, HIST1H3A, LEO1, PAF1, CUL4A, POLR2A, MDM2, ASB16, ASB9, SUZ12, EED, RNF2, APEH, SEC24D, TBCD, PARK2, VHL, UBD, ICAM1, CD81, IGSF8, EIF2AK2, ITGA4, IL7R, CSNK2A2, SMURF1, HIST1H2AD, H1FX, COPS5, CAND1, CUL1, CUL2, CUL3, CUL4B, CUL5, NEDD
Protein Size: 213
Molecular Weight 21 kDa
Gene ID 3006
NCBI Accession NM_005319, NP_005310
UniProt P16403
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 213 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Histone Cluster 1, H1c (HIST1H1C) (Middle Region) antibody (ABIN2782497) WB Suggested Anti-HIST1H1C Antibody Titration: 0.2-1 ug/ml
Positive Cont...
Background publications Kim, Choi, Heo, Kim, Levens, Kohno, Johnson, Brock, An: "Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription." in: The Journal of biological chemistry, Vol. 283, Issue 14, pp. 9113-26, 2008 (PubMed).

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