SMC4 antibody (Middle Region)

Catalog No. ABIN2782505

Product Details anti-SMC4 Antibody

Target: SMC4 (Structural Maintenance of Chromosomes 4 (SMC4))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Guinea Pig, Dog, Horse, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EARCHEMKPN LGAIAEYKKK EELYLQRVAE LDKITYERDS FRQAYEDLRK

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against SMC4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SMC4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1288 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMC4

Target: SMC4 (Structural Maintenance of Chromosomes 4 (SMC4))

Alternative Name: SMC4 (SMC4 Products)

Synonyms: CAP-C antibody, CAPC antibody, SMC-4 antibody, SMC4L1 antibody, hCAP-C antibody, 2500002A22Rik antibody, C79747 antibody, Smc4l1 antibody, cb788 antibody, chunp6901 antibody, fb99b10 antibody, smc4l1 antibody, wu:fb99b10 antibody, xcap-c antibody, ARABIDOPSIS THALIANA CHROMOSOME ASSOCIATED PROTEIN-C antibody, ARABIDOPSIS THALIANA STRUCTURAL MAINTENANCE OF CHROMOSOME 4 antibody, ATCAP-C antibody, ATSMC3 antibody, ATSMC4 antibody, K15N18.7 antibody, K15N18_7 antibody, STRUCTURAL MAINTENANCE OF CHROMOSOMES 3 antibody, structural maintenance of chromosome 3 antibody, Structural maintenance of chromosomes protein 4 antibody, structural maintenance of chromosomes 4 antibody, structural maintenance of chromosomes 4 L homeolog antibody, structural maintenance of chromosome 3 antibody, smc-4 antibody, SMC4 antibody, Smc4 antibody, smc4 antibody, smc4.L antibody, SMC3 antibody

Background: SMC4 is the central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Alias Symbols: CAPC, SMC4L1, hCAP-C, CAP-C, SMC-4
Protein Interaction Partner: UBC, SUMO2, LGR4, RPA3, RPA2, RPA1, RNF2, NCAPH, SMC2, SSSCA1, NCAPD2, TBC1D4, PLEC, AP3S1, CDK9, NCAPG, CCAR2, RABL6, TOPBP1, FBXO6, UBD, HDAC11, MYC, Nfe2l2, NEDD8, CDK2, SIRT7, NCAPH2, NCAPD3, RAD21, TRAF3IP1, SUMO1, HDAC1, tat, DNMT3B,
Protein Size: 1288

Molecular Weight: 147 kDa

Gene ID: 10051

NCBI Accession: NM_001002800, NP_001002800

UniProt: Q9NTJ3