TMPRSS11D antibody (N-Term)

Catalog No. ABIN2782621

Product Details anti-TMPRSS11D Antibody

Target: TMPRSS11D (Transmembrane Protease, serine 11D (TMPRSS11D))

Binding Specificity: N-Term

Reactivity: Human, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMPRSS11D antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: RSSFQLLNVE YNSQLNSPAT QEYRTLSGRI ESLITKTFKE SNLRNQFIRA

Predicted Reactivity: Guinea Pig: 79%, Horse: 79%, Human: 100%, Rabbit: 79%

Characteristics: This is a rabbit polyclonal antibody against TMPRSS11D. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TMPRSS11D

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 418 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TMPRSS11D antibody (ABIN2782621)

Matsushima, Takahashi, Nakaya, Maezawa, Miki, Nakamura, Ohgushi, Yasuoka: "Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 290, Issue 2, pp. L385-95, (2006) (PubMed).

Target Details for TMPRSS11D

Target: TMPRSS11D (Transmembrane Protease, serine 11D (TMPRSS11D))

Alternative Name: TMPRSS11D (TMPRSS11D Products)

Synonyms: HAT antibody, AST antibody, AsP antibody, BC020151 antibody, Asp antibody, Tmprss11d antibody, transmembrane protease, serine 11D antibody, transmembrane protease, serine 11d antibody, transmembrane protease serine 11D antibody, TMPRSS11D antibody, Tmprss11d antibody, LOC100720850 antibody

Background: TMPRSS11D is a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38 % identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38 % identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
Alias Symbols: HAT, MGC150587, MGC150588
Protein Size: 418

Molecular Weight: 46 kDa

Gene ID: 9407

NCBI Accession: NM_004262, NP_004253

UniProt: O60235

Pathways: Positive Regulation of Peptide Hormone Secretion, Regulation of Carbohydrate Metabolic Process