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ATP6V0A1 antibody (N-Term)

ATP6V0A1 Reactivity: Human, Mouse, Rat, Cow, Rabbit, Horse, Dog, Zebrafish (Danio rerio), Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2782670
  • Target See all ATP6V0A1 Antibodies
    ATP6V0A1 (ATPase, H+ Transporting, Lysosomal V0 Subunit A1 (ATP6V0A1))
    Binding Specificity
    • 4
    • 4
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Mouse, Rat, Cow, Rabbit, Horse, Dog, Zebrafish (Danio rerio), Guinea Pig
    Host
    • 8
    • 1
    Rabbit
    Clonality
    • 9
    Polyclonal
    Conjugate
    • 6
    • 1
    • 1
    • 1
    This ATP6V0A1 antibody is un-conjugated
    Application
    • 6
    • 5
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    RDLNPDVNVF QRKFVNEVRR CEEMDRKLRF VEKEIRKANI PIMDTGENPE
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against ATP6V0A1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human ATP6V0A1
    Top Product
    Discover our top product ATP6V0A1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 831 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Leiva-Rodríguez, Romeo-Guitart, Marmolejo-Martínez-Artesero, Herrando-Grabulosa, Bosch, Forés, Casas: "ATG5 overexpression is neuroprotective and attenuates cytoskeletal and vesicle-trafficking alterations in axotomized motoneurons." in: Cell death & disease, Vol. 9, Issue 6, pp. 626, (2019) (PubMed).

    Antonacopoulou, Grivas, Skarlas, Kalofonos, Scopa, Kalofonos: "POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?" in: Anticancer research, Vol. 28, Issue 2B, pp. 1221-7, (2008) (PubMed).

  • Target
    ATP6V0A1 (ATPase, H+ Transporting, Lysosomal V0 Subunit A1 (ATP6V0A1))
    Alternative Name
    ATP6V0A1 (ATP6V0A1 Products)
    Synonyms
    ATP6N1 antibody, ATP6N1A antibody, Stv1 antibody, VPP1 antibody, Vph1 antibody, a1 antibody, AA959968 antibody, ATP6a1 antibody, Atp6n1 antibody, Atp6n1a antibody, Atpv0a1 antibody, Vpp-1 antibody, Vpp1 antibody, A1 antibody, wu:fj37e01 antibody, zgc:112214 antibody, atp6v0a1 antibody, wu:fc25b09 antibody, zgc:76965 antibody, ATPase H+ transporting V0 subunit a1 antibody, ATPase, H+ transporting, lysosomal V0 subunit A1 antibody, si:ch73-173p19.2 antibody, ATPase, H+ transporting, lysosomal V0 subunit a1 L homeolog antibody, ATPase, H+ transporting, lysosomal V0 subunit a1b antibody, ATPase, H+ transporting, lysosomal V0 subunit a1a antibody, ATP6V0A1 antibody, Atp6v0a1 antibody, si:ch73-173p19.2 antibody, atp6v0a1.L antibody, atp6v0a1b antibody, atp6v0a1a antibody
    Background
    ATP6V0A1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. ATP6V0A1 is one of three A subunit proteins and it is associated with clathrin-coated vesicles. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. The occurrence of splice variants encoding different protein products has been reported, but the full-length natures of these transcripts have not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: ATP6N1, ATP6N1A, DKFZp781J1951, Stv1, VPP1, Vph1, a1
    Protein Interaction Partner: SEH1L, ZNF267, SNX4, UBC, CLIC1, MARCKSL1, MRPL44, SLC30A5, MRPL50, PTRH2, ATP6V1D, MRPL46, SCFD1, VAMP2, SRSF3, RPS18, RPS15, SLC25A3, PA2G4, NONO, ATP6V1E1, ATP6V1B1,
    Protein Size: 831
    Molecular Weight
    96 kDa
    Gene ID
    535
    NCBI Accession
    NM_005177, NP_005168
    UniProt
    Q93050
    Pathways
    Transition Metal Ion Homeostasis, Proton Transport
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