DDOST antibody (N-Term)

Catalog No. ABIN2782672

Product Details anti-DDOST Antibody

Target: DDOST (Dolichyl-diphosphooligosaccharide--Protein Glycosyltransferase (DDOST))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Rabbit, Cow, Sheep, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDOST antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SPSVEDFGGN INVETISAFI DGGGSVLVAA SSDIGDPLRE LGSECGIEFD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against DDOST. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DDOST

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 456 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DDOST

Target: DDOST (Dolichyl-diphosphooligosaccharide--Protein Glycosyltransferase (DDOST))

Alternative Name: DDOST (DDOST Products)

Synonyms: AGER1 antibody, CDG1R antibody, OKSWcl45 antibody, OST antibody, OST48 antibody, WBP1 antibody, DDOST antibody, wu:fa11d01 antibody, zgc:66068 antibody, zgc:77478 antibody, Ddost antibody, CG9022 antibody, DmOST50 antibody, Dmel\\CG9022 antibody, DrOST antibody, OST48/WBP1 antibody, Ots48 antibody, anon-EST:Liang-1.11 antibody, clone 1.11 antibody, ost48 antibody, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit antibody, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) S homeolog antibody, dolichyl-diphosphooligosaccharide-protein glycosyltransferase antibody, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) antibody, dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit antibody, dolichyl-di-phosphooligosaccharide-protein glycotransferase antibody, Oligosaccharyltransferase 48kD subunit antibody, DDOST antibody, ddost.S antibody, GTR26 antibody, ddost antibody, Ddost antibody, LOC5580056 antibody, PTRG_01946 antibody, Ost48 antibody

Background: DDOST is a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. DDOST is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.
Alias Symbols: AGE-R1, KIAA0115, MGC2191, OK/SW-cl.45, OST, OST48, WBP1, AGER1, OKSWcl45
Protein Interaction Partner: HUWE1, VAPB, UBC, FAF1, STAU1, ASB11, TRIM13, SUZ12, EED, CLN3, NXT1, SRSF11, FN1, ATF2, STT3B, MAGT1, ZMPSTE24, VDAC2, SSR4, SSR3, SLC25A3, ILF2, KRTCAP2, FBXO6, UBD, AMFR, AUP1, TMEM173, UNC93B1, MAPK6, HDAC5, AGO3, BRCC3, GSTK1, TMBIM4, PGRMC1, SAP18,
Protein Size: 456

Molecular Weight: 46 kDa

Gene ID: 1650

NCBI Accession: NM_005216, NP_005207

UniProt: Q5VWA5

Pathways: Cell RedoxHomeostasis