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SPTLC1 antibody (Middle Region)

SPTLC1 Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio), Dog, Saccharomyces cerevisiae WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2782713
  • Target See all SPTLC1 Antibodies
    SPTLC1 (serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1))
    Binding Specificity
    • 15
    • 10
    • 9
    • 7
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 64
    • 19
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio), Dog, Saccharomyces cerevisiae
    Host
    • 64
    • 1
    Rabbit
    Clonality
    • 64
    • 1
    Polyclonal
    Conjugate
    • 24
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SPTLC1 antibody is un-conjugated
    Application
    • 58
    • 31
    • 13
    • 13
    • 8
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    ICPLPELVKL KYKYKARIFL EESLSFGVLG EHGRGVTEHY GINIDDIDLI
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 93%
    Characteristics
    This is a rabbit polyclonal antibody against SPTLC1. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human SPTLC1
    Top Product
    Discover our top product SPTLC1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 473 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    SPTLC1 (serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1))
    Alternative Name
    SPTLC1 (SPTLC1 Products)
    Synonyms
    ATSPT1 antibody, SERINE PALMITOYLTRANSFERASE 1 antibody, serine palmitoyltransferase 1 antibody, Afu6g00300 antibody, HSAN1 antibody, HSN1 antibody, LBC1 antibody, LCB1 antibody, SPT1 antibody, SPTI antibody, wu:fc75h04 antibody, wu:fp41c08 antibody, zgc:112247 antibody, AW552086 antibody, C77762 antibody, E030036H05 antibody, Lcb1 antibody, RGD1306617 antibody, Spt1 antibody, serine palmitoyltransferase 1 antibody, Serine palmitoyltransferase 1 antibody, serine palmitoyltransferase long chain base subunit 1 antibody, serine palmitoyltransferase, long chain base subunit 1 antibody, serine palmitoyltransferase, long chain base subunit 1 L homeolog antibody, SPT1 antibody, AFUA_6G00300 antibody, PAS_FragB_0040 antibody, SPTLC1 antibody, sptlc1 antibody, sptlc1.L antibody, Sptlc1 antibody
    Background
    Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPTLC1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 gene were identified in patients with hereditary sensory neuropathy type 1.Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
    Alias Symbols: HSAN, HSAN1, HSN1, LBC1, LCB1, MGC14645, SPT1, SPTI, hLCB1
    Protein Interaction Partner: UBC, FBXO6, EGFR, ADRB2, CFTR, ABCA1, UBD, AUP1, MYC, ATG4C, ORMDL3, SPTLC2, C20orf24, MAGED1, RGS20,
    Protein Size: 473
    Molecular Weight
    53 kDa
    Gene ID
    10558
    NCBI Accession
    NM_006415, NP_006406
    UniProt
    O15269
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