PTPRE antibody (Middle Region)

Catalog No. ABIN2782718

Product Details anti-PTPRE Antibody

Target: PTPRE (Protein tyrosine Phosphatase, Receptor Type, E (PTPRE))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Cow, Dog, Horse, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRE antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VILSMKRGQE YTDYINASFI DGYRQKDYFI ATQGPLAHTV EDFWRMIWEW

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PTPRE. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PTPRE

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 700 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PTPRE

Target: PTPRE (Protein tyrosine Phosphatase, Receptor Type, E (PTPRE))

Alternative Name: PTPRE (PTPRE Products)

Synonyms: ptpra antibody, HPTPE antibody, PTPE antibody, R-PTP-EPSILON antibody, PTPe antibody, PTPepsilon antibody, RPTPepsilon antibody, protein tyrosine phosphatase, receptor type E L homeolog antibody, protein tyrosine phosphatase, receptor type E antibody, protein tyrosine phosphatase, receptor type, E antibody, ptpre.L antibody, PTPRE antibody, Ptpre antibody

Background: PTPRE is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.
Alias Symbols: DKFZp313F1310, HPTPE, PTPE, R-PTP-EPSILON
Protein Interaction Partner: UBC, MAPK3, MAPK1, KCNB1, KCNA5, PTPRD, PTPRS, PTPRE, SRC, YES1, FYN, GRB2,
Protein Size: 700

Molecular Weight: 81 kDa

Gene ID: 5791

NCBI Accession: NM_006504, NP_006495

UniProt: P23469