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KIRREL antibody (Middle Region)

NEPH1 Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2782952
  • Target See all KIRREL (NEPH1) Antibodies
    KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))
    Binding Specificity
    • 14
    • 10
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 18
    • 9
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit
    Host
    • 25
    Rabbit
    Clonality
    • 25
    Polyclonal
    Conjugate
    • 11
    • 4
    • 4
    • 2
    • 2
    • 2
    This KIRREL antibody is un-conjugated
    Application
    • 23
    • 19
    • 6
    • 5
    • 5
    • 5
    • 5
    • 1
    Western Blotting (WB)
    Sequence
    FLEVGTLERY TVERTNSGSG VLSTLTINNV MEADFQTHYN CTAWNSFGPG
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against KIRREL. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human KIRREL
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 757 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Ito, Sugihara, Asaka, Toyama, Yoshihara, Furuichi, Wada, Asano: "Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice." in: PLoS ONE, Vol. 7, Issue 1, pp. e29873, (2012) (PubMed).

  • Target
    KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))
    Alternative Name
    KIRREL (NEPH1 Products)
    Synonyms
    NEPH1 antibody, 6720469N11Rik antibody, Kirrel1 antibody, Neph1 antibody, nephrin related antibody, kirre like nephrin family adhesion molecule 1 antibody, kin of IRRE like (Drosophila) antibody, Smp_104390 antibody, Smp_140170 antibody, KIRREL1 antibody, Kirrel antibody, Kirrel1 antibody
    Background
    KIRREL (NEPH1) is a member of the nephrin-like protein family, which includes NEPH2 and NEPH3. The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2, MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-337 AY302131.1 1-337 338-3211 BC109193.1 1-2874 3212-3609 AK001707.1 1904-2301 3610-3628 BC082969.1 2273-2291
    Alias Symbols: FLJ10845, MGC129542, MGC129543, NEPH1
    Protein Interaction Partner: UBC, SAV1, LATS1, GRB2, KIRREL, NPHS2, NPHS1, TJP1,
    Protein Size: 757
    Molecular Weight
    84 kDa
    Gene ID
    55243
    NCBI Accession
    NM_018240, NP_060710
    UniProt
    Q96J84
    Pathways
    Regulation of Actin Filament Polymerization
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