MORF4L1 antibody (Middle Region)

Catalog No. ABIN2783048

Product Details anti-MORF4L1 Antibody

Target: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MORF4L1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PEELKPWLVD DWDLITRQKQ LFYLPAKKNV DSILEDYANY KKSRGNTDNK

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 93%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against Morf4l1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 362 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MORF4L1

Target: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Alternative Name: Morf4l1 (MORF4L1 Products)

Synonyms: Eaf3 antibody, HsT17725 antibody, MEAF3 antibody, MORFRG15 antibody, MRG15 antibody, S863-6 antibody, TEG-189 antibody, Tex189 antibody, mKIAA4002 antibody, MORF4L2 antibody, CG6363 antibody, DmMRG15 antibody, Dmel\\CG6363 antibody, Dmrg15 antibody, Mrg15 antibody, dMRG15 antibody, dMrg15 antibody, l(3)j6A3 antibody, zgc:92289 antibody, mortality factor 4 like 1 antibody, MORF-related gene 15 antibody, MRG15 antibody, mortality factor 4 like 1 S homeolog antibody, MORF4L1 antibody, Morf4l1 antibody, MRG15 antibody, CpipJ_CPIJ013367 antibody, morf4l1.S antibody, morf4l1 antibody

Background: Morf4l1 is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Alias Symbols: KIAA4002, MGC102415, MGC103105, MGC118047, MORFRG15, MRG15, TEG-189, Tex189, mKIAA4002
Protein Interaction Partner: Nanog, Hdac1, Phf12, Sin3b, Rb1, MRFAP1, Vezf1, Rnf2, Kdm5b, SIN3A, TLE1, PFN2,
Protein Size: 362

Molecular Weight: 41 kDa

Gene ID: 21761

NCBI Accession: NM_001039147, NP_001034236

UniProt: P60762

Pathways: Chromatin Binding