PSMC3IP antibody (Middle Region)

Catalog No. ABIN2783050

Product Details anti-PSMC3IP Antibody

Target: PSMC3IP (PSMC3 Interacting Protein (PSMC3IP))

Binding Specificity: Middle Region

Reactivity: Mouse, Human, Rat, Dog, Cow, Horse, Rabbit, Goat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC3IP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RLKNIKAATN HVTPEEKEQV YRERQKYCKE WRKRKRMATE LSDAILEGYP

Predicted Reactivity: Cow: 93%, Dog: 100%, Goat: 86%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against PSMC3IP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PSMC3IP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 217 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMC3IP

Target: PSMC3IP (PSMC3 Interacting Protein (PSMC3IP))

Alternative Name: PSMC3IP (PSMC3IP Products)

Background: PSMC3IP plays an important role in meiotic recombination. It stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.
Alias Symbols: GT198, HOP2, TBPIP, ODG3, HUMGT198A
Protein Interaction Partner: PSMC3, PSMC3IP, THRB, ESR2, AR, RXRA, NR3C1,
Protein Size: 217

Molecular Weight: 25 kDa

Gene ID: 29893

NCBI Accession: NM_016556, NP_057640

UniProt: Q9P2W1