PPP1R13B antibody (Middle Region)

Catalog No. ABIN2783179

Product Details anti-PPP1R13B Antibody

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Horse, Cow, Dog, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1R13B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EFDLVQRIIY EVEDPSKPND EGITPLHNAV CAGHHHIVKF LLDFGVNVNA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against PPP1R13B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PPP1R13B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1090 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PPP1R13B

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Alternative Name: PPP1R13B (PPP1R13B Products)

Synonyms: ASPP1 antibody, p53BP2-like antibody, p85 antibody, AI449786 antibody, AW545810 antibody, Tp53bp2 antibody, Trp53bp2 antibody, protein phosphatase 1 regulatory subunit 13B antibody, protein phosphatase 1, regulatory subunit 13B antibody, protein phosphatase 1 regulatory subunit 13B L homeolog antibody, protein phosphatase 1, regulatory subunit 13Bb antibody, protein phosphatase 1, regulatory (inhibitor) subunit 13B antibody, PPP1R13B antibody, Ppp1r13b antibody, ppp1r13b.L antibody, ppp1r13bb antibody, ppp1r13b antibody

Background: PPP1R13B is a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
Alias Symbols: ASPP1, KIAA0771, p53BP2-like, p85
Protein Interaction Partner: TRAF1, CCDC184, MIPOL1, LATS2, SIAH2, PPP1CC, PPP1CA, HRAS, LATS1, KHDRBS1, ERBB2, CEP63, TNIK, CDC5L, UBC, PLEKHA5, APC, TP63, TP73, E2F4, E2F3, E2F2, E2F1,
Protein Size: 1090

Molecular Weight: 119 kDa

Gene ID: 23368

NCBI Accession: NM_015316, NP_056131

UniProt: Q96KQ4

Pathways: p53 Signaling