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PDHA1 antibody (C-Term)

PDHA1 Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Zebrafish (Danio rerio), Guinea Pig, Rabbit, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2783236
  • Target See all PDHA1 Antibodies
    PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))
    Binding Specificity
    • 30
    • 15
    • 12
    • 12
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 105
    • 52
    • 51
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Pig, Zebrafish (Danio rerio), Guinea Pig, Rabbit, Horse
    Host
    • 102
    • 7
    Rabbit
    Clonality
    • 93
    • 16
    Polyclonal
    Conjugate
    • 40
    • 9
    • 8
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PDHA1 antibody is un-conjugated
    Application
    • 95
    • 44
    • 16
    • 15
    • 14
    • 14
    • 13
    • 11
    • 9
    • 7
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 82%
    Characteristics
    This is a rabbit polyclonal antibody against PDHA1. It was validated on Western Blot using a cell lysate as a positive control.
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human PDHA1
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    Discover our top product PDHA1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 390 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))
    Alternative Name
    PDHA1 (PDHA1 Products)
    Synonyms
    PDHA antibody, PDHCE1A antibody, PHE1A antibody, Pdha-1 antibody, pdha antibody, phe1a antibody, pdhce1a antibody, im:6895726 antibody, pdha1 antibody, wu:fd18b01 antibody, wu:fo96f03 antibody, zgc:73271 antibody, zgc:86692 antibody, Pdha1 antibody, wu:fp73b04 antibody, zgc:92705 antibody, NI36_05250 antibody, pdha1-a antibody, pdha1-b antibody, pyruvate dehydrogenase E1 alpha 1 subunit antibody, pyruvate dehydrogenase E1 alpha 1 antibody, pyruvate dehydrogenase (lipoamide) alpha 1 antibody, pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene antibody, 2-oxo acid dehydrogenase antibody, pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha antibody, pyruvate dehydrogenase alpha subunit protein antibody, pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit antibody, precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit antibody, pyruvate dehydrogenase antibody, pyruvate dehydrogenase E1 alpha 1 subunit a antibody, pyruvate dehydrogenase E1 alpha 1 subunit b antibody, pyruvate dehydrogenase E1 component subunit alpha antibody, pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog antibody, PDHA1 antibody, Pdha1 antibody, pdha1 antibody, LOC719277 antibody, VNG_RS07485 antibody, RR_RS04695 antibody, pdhA1 antibody, pdha1a antibody, pdha1b antibody, NI36_RS05240 antibody, pdha1.S antibody
    Background
    The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1), dihydrolipoyl transacetylase (DLAT), and dihydrolipoyl dehydrogenase (DLD). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex.The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1), dihydrolipoyl transacetylase (DLAT, MIM 608770) (E2, EC 2.3.1.12), and dihydrolipoyl dehydrogenase (DLD, MIM 238331) (E3, EC 1.8.1.4). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994 [PubMed 7853374]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: PDHA, PDHCE1A, PHE1A
    Protein Interaction Partner: HUWE1, SUMO2, UBC, GINS4, DCPS, NCDN, VCL, PPP1R2, MSN, ASL, ADRB2, ITGA4, HNRNPDL, PDHX, SDHA, PDHB, OGDH, GTF2I, DLAT, CUL3, SIRT7, ATG101, WDR20, BABAM1, USP19, PDP1, EIF6, PDK4, PDK3, PDK2, PDK1, PDHA1, DGKE,
    Protein Size: 390
    Molecular Weight
    40 kDa
    Gene ID
    5160
    NCBI Accession
    NM_000284, NP_000275
    UniProt
    P08559
    Pathways
    Warburg Effect
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