TPM2 antibody (C-Term)

Catalog No. ABIN2783288

Product Details anti-TPM2 Antibody

Target: TPM2 (Tropomyosin-2 (TPM2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Horse, Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: AETRAEFAER SVAKLEKTID DLEDEVYAQK MKYKAISEEL DNALNDITSL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 85%, Human: 100%, Mouse: 100%, Pig: 85%, Rabbit: 100%, Rat: 100%, Sheep: 85%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against TPM2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TPM2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 284 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TPM2 antibody (ABIN2783288)

Abdul-Hussein, Rahl, Moslemi, Tajsharghi: "Phenotypes of myopathy-related beta-tropomyosin mutants in human and mouse tissue cultures." in: PLoS ONE, Vol. 8, Issue 9, pp. e72396, (2013) (PubMed).

Tajsharghi, Ohlsson, Lindberg, Oldfors: "Congenital myopathy with nemaline rods and cap structures caused by a mutation in the beta-tropomyosin gene (TPM2)." in: Archives of neurology, Vol. 64, Issue 9, pp. 1334-8, (2007) (PubMed).

Target Details for TPM2

Target: TPM2 (Tropomyosin-2 (TPM2))

Alternative Name: TPM2 (TPM2 Products)

Synonyms: CG4843 antibody, DROTROPI1 antibody, Dmel\\CG4843 antibody, Ifm(3)3 antibody, Ifm(3)5 antibody, Ifm-TmI antibody, TM2 antibody, Tm antibody, Tm1 antibody, Tm127 antibody, TmI antibody, TmII antibody, Tn-H antibody, dro Tm antibody, l(3)nc99Eb antibody, mTmI antibody, cb836 antibody, fb68h02 antibody, tpm4l antibody, wu:fb68h02 antibody, wu:fj63f03 antibody, zgc:86810 antibody, AMCD1 antibody, DA1 antibody, DA2B antibody, TMSB antibody, nem4 antibody, tpm2 antibody, tpm2a antibody, BRT-2 antibody, TPM3 antibody, NEM4 antibody, Tpm-2 antibody, Trop-2 antibody, Tropomyosin 2 antibody, Tropomyosin-2 antibody, tropomyosin antibody, tropomyosin 2 (beta) antibody, tropomyosin 2 L homeolog antibody, tropomyosin 2 antibody, tropomyosin 2, beta antibody, Tm2 antibody, EDI_309330 antibody, LOC100101174 antibody, tpm2 antibody, tpm2.L antibody, TPM2 antibody, Tpm2 antibody

Background: TPM2 is beta-tropomyosin, an isoform of tropomyosin that is mainly expressed in slow, type 1 muscle fibers.The TPM2 gene encodes beta-tropomyosin, an isoform of tropomyosin that is mainly expressed in slow, type 1 muscle fibers (Tajsharghi et al., 2007 [PubMed 17846275]). See also TPM1 (MIM 191010), TPM3 (MIM 191030), and TPM4 (MIM 600317).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AMCD1, DA1, TMSB, DA2B, NEM4
Protein Interaction Partner: UBC, RPA3, RPA2, RPA1, HECTD1, SKIL, STAM, TPM4, TPM3, TPM1, SULT1A1, NONO, STMN1, DYNC1H1, DDX3X, DDB1, SRXN1, CPSF7, CORO1B, DSTN, SF3B2, AHCYL1, DDX46, TAF15, LRRK2, AKT1, SP1, ACTA1, S100A4, TPM2, PDLIM7, PIK3CG, RRAD, S100A2, JUN, ADRBK1, ACTB,
Protein Size: 284

Molecular Weight: 33 kDa

Gene ID: 7169

NCBI Accession: NM_003289, NP_003280

UniProt: P07951