SNAP23 antibody (N-Term)

Catalog No. ABIN2783437

Product Details anti-SNAP23 Antibody

Target: SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNAP23 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GIKTITMLDE QKEQLNRIEE GLDQINKDMR ETEKTLTELN KCCGLCVCPC

Predicted Reactivity: Cow: 79%, Dog: 86%, Guinea Pig: 86%, Horse: 92%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 86%, Yeast: 83%, Zebrafish: 90%

Characteristics: This is a rabbit polyclonal antibody against SNAP23. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SNAP23

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 211 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SNAP23

Target: SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))

Alternative Name: SNAP23 (SNAP23 Products)

Synonyms: 23kDa antibody, AA408749 antibody, SNAP-23 antibody, Sndt antibody, Syndet antibody, HsT17016 antibody, SNAP23A antibody, SNAP23B antibody, XOSNAP-23 antibody, snap23-A antibody, synaptosome associated protein 23 antibody, synaptosome associated protein 23kDa antibody, synaptosomal-associated protein 23 antibody, synaptosome associated protein 23kDa L homeolog antibody, SNAP23 antibody, snap23 antibody, Snap23 antibody, snap23.L antibody

Background: SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Alias Symbols: HsT17016, SNAP23A, SNAP23B, SNAP-23
Protein Interaction Partner: VAMP5, SNAP23, STX11, UBC, NAPB, STX1A, FN1, ILF2, HNRNPAB, ANXA3, C12orf57, UBQLN2, SCFD1, SYNCRIP, FAM3C, YES1, STX4, SRSF1, PSAP, CEP97, CCP110, ELAVL1, WASH2P, MATR3, NSF, STX3, TLK1, SCGN, ABI2, STX6, KIF5B, STXBP5, SNAPIN, SCAMP2, SCAMP1, STX12, ABI
Protein Size: 211

Molecular Weight: 23 kDa

Gene ID: 8773

NCBI Accession: NM_003825, NP_003816

UniProt: O00161