POLD2 antibody (N-Term)

Catalog No. ABIN2783466

Product Details anti-POLD2 Antibody

Target: POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Rabbit, Cow, Guinea Pig, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLD2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LREVSEEHNL LPQPPRSKYI HPDDELVLED ELQRIKLKGT IDVSKLVTGT

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against POLD2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human POLD2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 469 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for POLD2

Target: POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))

Alternative Name: POLD2 (POLD2 Products)

Synonyms: 50kDa antibody, p50 antibody, po1D2 antibody, cdc1 antibody, si:dz150f13.3 antibody, zgc:55633 antibody, zgc:77043 antibody, DNA polymerase delta 2, accessory subunit antibody, polymerase (DNA directed), delta 2, regulatory subunit antibody, polymerase (DNA directed), delta 2, accessory subunit L homeolog antibody, POLD2 antibody, Pold2 antibody, pold2.L antibody, pold2 antibody

Background: This protein is a DNA polymerase delta complex ,it involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen, the multisubunit replication factor C, and the 4 subunit polymerase complex: POLD1, POLD2, POLD3, and POLD4The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA, MIM 176740), the multisubunit replication factor C (see MIM 102579), and the 4 subunit polymerase complex: POLD1 (MIM 174761), POLD2, POLD3 (MIM 611415), and POLD4 (MIM 611525) (Liu and Warbrick, 2006 [PubMed 16934752]).[supplied by OMIM].
Alias Symbols: -
Protein Interaction Partner: UBC, SPRTN, FOXK1, FAM129A, XRN1, POLD1, MMS19, POLD4, CCHCR1, SOX12, EP300, UBD, BBLF2-BBLF3, POLD3, PCNA, POLDIP3, POLDIP2, KCTD13, WRNIP1, LSM6, WRN, CDK2, CDKN1A,
Protein Size: 469

Molecular Weight: 51 kDa

Gene ID: 5425

NCBI Accession: NM_006230, NP_006221

UniProt: P49005

Pathways: Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA