QPCT antibody (Middle Region)

Catalog No. ABIN2783489

Product Details anti-QPCT Antibody

Target: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Sheep, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This QPCT antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SRHLAAKMAS TPHPPGARGT SQLHGMDLLV LLDLIGAPNP TFPNFFPNSA

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 100%, Sheep: 86%

Characteristics: This is a rabbit polyclonal antibody against QPCT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human QPCT

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 361 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for QPCT

Target: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Alternative Name: QPCT (QPCT Products)

Synonyms: GCT antibody, QC antibody, sQC antibody, QPCT antibody, 5730422A13Rik antibody, Qpctl1 antibody, RGD1562284 antibody, qpct antibody, glutaminyl-peptide cyclotransferase antibody, glutaminyl-peptide cyclotransferase (glutaminyl cyclase) antibody, glutaminyl-peptide cyclotransferase L homeolog antibody, QPCT antibody, Qpct antibody, M6_Spy0443 antibody, M5005_Spy_0416 antibody, M28_Spy0404 antibody, CJA_2408 antibody, CCNA_02733 antibody, Tsp_03182 antibody, qpct.L antibody

Background: QPCT is responsible for the biosynthesis of pyroglutamyl peptides. QPCT has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. It also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. QPCT may be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86 % identical to that of bovine glutaminyl cyclase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GCT, QC, sQC
Protein Interaction Partner: CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, NEDD8, UBC,
Protein Size: 361

Molecular Weight: 38 kDa

Gene ID: 25797

NCBI Accession: NM_012413, NP_036545

UniProt: Q16769