NUDT15 antibody (N-Term)

Catalog No. ABIN2783521

Product Details anti-NUDT15 Antibody

Target: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUDT15 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RKGSFGAGSF QLPGGHLEFG ETWEECAQRE TWEEAGLHLK NVCFASVVNS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against Nudt15. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 170 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NUDT15

Target: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Alternative Name: Nudt15 (NUDT15 Products)

Synonyms: MTH2 antibody, RP11-90M2.1 antibody, 6530403O17 antibody, A730068G11Rik antibody, nudix hydrolase 15 antibody, nudix (nucleoside diphosphate linked moiety X)-type motif 15 antibody, NUDT15 antibody, Nudt15 antibody

Background: Nudt15 mediates the hydrolysis of some nucleoside diphosphate derivatives. It can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. Nudt15 may have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.
Alias Symbols: 6530403O17, A730068G11Rik, MTH2
Protein Size: 170

Molecular Weight: 19 kDa

Gene ID: 214254

NCBI Accession: NM_172527, NP_766115

UniProt: Q8BG93