PCDHGB1 antibody (N-Term)

Catalog No. ABIN2783725

Product Details anti-PCDHGB1 Antibody

Target: PCDHGB1 (Protocadherin gamma Subfamily B, 1 (PCDHGB1))

Binding Specificity: N-Term

Reactivity: Human, Rabbit, Cow, Dog, Guinea Pig, Horse, Mouse, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGB1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SPDGSKYPVL LLEKPLDREH QSSHRLILTA MDGGDPPLSG TTHIWIRVTD

Predicted Reactivity: Cow: 85%, Dog: 92%, Guinea Pig: 90%, Horse: 83%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against PCDHGB1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCDHGB1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 810 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDHGB1

Target: PCDHGB1 (Protocadherin gamma Subfamily B, 1 (PCDHGB1))

Alternative Name: PCDHGB1 (PCDHGB1 Products)

Background: PCDHGB1 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHGB1 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Alias Symbols: MGC119466, MGC119467, MGC119469, PCDH-GAMMA-B1
Protein Size: 810

Molecular Weight: 85 kDa

Gene ID: 56104

NCBI Accession: NM_032095, NP_115266

UniProt: Q3SY75