PCDHB14 antibody (Middle Region)

Catalog No. ABIN2783731

Product Details anti-PCDHB14 Antibody

Target: PCDHB14 (Protocadherin beta 14 (PCDHB14))

Binding Specificity: Middle Region

Reactivity: Human, Cow, Dog, Horse, Mouse, Pig, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHB14 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YGKISYTFFH ASEDIRKTFE INPISGEVNL RSPLDFEVIQ SYTINIQATD

Predicted Reactivity: Cow: 86%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PCDHB14. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PCDHB14

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDHB14

Target: PCDHB14 (Protocadherin beta 14 (PCDHB14))

Alternative Name: PCDHB14 (PCDHB14 Products)

Background: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
Alias Symbols: PCDH-BETA14
Protein Size: 645

Molecular Weight: 70 kDa

Gene ID: 56122

NCBI Accession: NM_018934, NP_061757

UniProt: B4DPE2