LRRC8A antibody (N-Term)

Catalog No. ABIN2783752

Product Details anti-LRRC8A Antibody

Target: LRRC8A (Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC8A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IPVTELRYFA DTQPAYRILK PWWDVFTDYI SIVMLMIAVF GGTLQVTQDK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against LRRC8A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LRRC8A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 810 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for LRRC8A

Target: LRRC8A (Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A))

Alternative Name: LRRC8A (LRRC8A Products)

Synonyms: AGM5 antibody, LRRC8 antibody, Lrrc8 antibody, mKIAA1437 antibody, wu:fb18g12 antibody, wu:fi21b10 antibody, LLRC8A antibody, leucine rich repeat containing 8 VRAC subunit A antibody, leucine rich repeat containing 8A antibody, leucine rich repeat containing 8 VRAC subunit Aa antibody, leucine-rich repeat containing 8 family member A S homeolog antibody, leucine rich repeat containing 8 family member A antibody, LRRC8A antibody, Lrrc8a antibody, lrrc8aa antibody, lrrc8a.S antibody

Background: LRRC8A is a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. LRRC8A is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Alias Symbols: FLJ10337, KIAA1437, LRRC8, AGM5
Protein Interaction Partner: SDHA, ELAVL1, UBC,
Protein Size: 810

Molecular Weight: 94 kDa

Gene ID: 56262

NCBI Accession: NM_019594, NP_062540

UniProt: Q8IWT6