ULBP1 antibody (N-Term)

Catalog No. ABIN2783974

Product Details anti-ULBP1 Antibody

Target: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULBP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MAAAASPAFL LCLPLLHLLS GWSRAGWVDT HCLCYDFIIT PKSRPEPQWC

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against ULBP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ULBP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 244 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ULBP1

Target: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Alternative Name: ULBP1 (ULBP1 Products)

Synonyms: RAET1I antibody, A430108B07Rik antibody, MULT1 antibody, ULBP1 antibody, UL16 binding protein 1 antibody, UL16 binding protein 21 antibody, NKG2D ligand 1 antibody, ULBP1 antibody, ULBP21 antibody, Ulbp1 antibody, LOC100683099 antibody

Background: ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Alias Symbols: RAET1I
Protein Interaction Partner: MARCH9, MARCH4, UBC, RAET1G, KLRC4,
Protein Size: 244

Molecular Weight: 28 kDa

Gene ID: 80329

NCBI Accession: NM_025218, NP_079494

UniProt: Q9BZM6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process