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NUMA1 antibody (C-Term)

NUMA1 Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Dog, Cow, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2784222
  • Target See all NUMA1 Antibodies
    NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))
    Binding Specificity
    • 15
    • 15
    • 7
    • 7
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 80
    • 18
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Guinea Pig, Horse, Dog, Cow, Rabbit
    Host
    • 67
    • 13
    Rabbit
    Clonality
    • 68
    • 12
    Polyclonal
    Conjugate
    • 34
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This NUMA1 antibody is un-conjugated
    Application
    • 28
    • 27
    • 26
    • 18
    • 16
    • 15
    • 14
    • 8
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    AQRLQAQLNE LQAQLSQKEQ AAEHYKLQME KAKTHYDAKK QQNQELQEQL
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against NUMA1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human NUMA1
    Top Product
    Discover our top product NUMA1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 2115 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Kilpivaara, Rantanen, Tamminen, Aittomäki, Blomqvist, Nevanlinna: "Comprehensive analysis of NuMA variation in breast cancer." in: BMC cancer, Vol. 8, pp. 71, (2008) (PubMed).

  • Target
    NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))
    Alternative Name
    NUMA1 (NUMA1 Products)
    Synonyms
    NUMA antibody, 6720401E04Rik antibody, AA764025 antibody, AL022610 antibody, AU014979 antibody, NUMA1 antibody, NuMA antibody, SP-H antibody, numa antibody, numa1 antibody, nuclear mitotic apparatus protein 1 antibody, nuclear mitotic apparatus protein 1 S homeolog antibody, NUMA1 antibody, Numa1 antibody, numa1 antibody, numa1.S antibody
    Background
    NuMA is a structural element in maintaining nuclear integrity. A critical spindle pole-associated mechanism, called the END (Emi1/NuMA/dynein-dynactin) network, spatially restricts APC/C activity in early mitosis. The entire coding region and exon-intron boundaries of NuMa were screened in 92 familial breast cancer patients. But the results do not support the role of NuMA variants as breast cancer susceptibility alleles.
    Alias Symbols: NUMA
    Protein Interaction Partner: CCDC57, GMCL1, BRAP, DVL3, DVL2, DVL1, UBC, LGR4, ERG, RPA3, RPA2, RPA1, RNF2, EZH2, BMI1, SUZ12, EED, YWHAQ, LMNA, CBX6, WHSC1, HSP90AB1, HSP90AA1, ESR1, CDK6, VCP, SMURF1, MDC1, TP53BP1, ECT2, NCSTN, DDB1, EMILIN1, DYNLL1, RAE1, NUP98, CDK2, TERF2IP, TE
    Protein Size: 2115
    Molecular Weight
    238 kDa
    Gene ID
    4926
    NCBI Accession
    NM_006185, NP_006176
    UniProt
    Q14980
    Pathways
    Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, M Phase
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