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SENP6 antibody (C-Term)

SENP6 Reactivity: Human, Cow, Horse, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2784245
  • Target See all SENP6 Antibodies
    SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
    Binding Specificity
    • 17
    • 8
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 52
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Cow, Horse, Pig
    Host
    • 48
    • 2
    • 2
    Rabbit
    Clonality
    • 50
    • 2
    Polyclonal
    Conjugate
    • 22
    • 6
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SENP6 antibody is un-conjugated
    Application
    • 37
    • 31
    • 24
    • 8
    • 5
    • 3
    • 1
    Western Blotting (WB)
    Sequence
    MNLANWFPPP RMRTKREEIR NIILKLQEDQ SKEKRKHKDT YSTEAPLGEG
    Predicted Reactivity
    Cow: 79%, Horse: 79%, Human: 100%, Pig: 91%
    Characteristics
    This is a rabbit polyclonal antibody against SENP6. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human SENP6
    Top Product
    Discover our top product SENP6 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1105 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
    Alternative Name
    SENP6 (SENP6 Products)
    Synonyms
    SSP1 antibody, SUSP1 antibody, 2810017C20Rik antibody, E130319N12Rik antibody, Susp1 antibody, mKIAA0797 antibody, fc83h02 antibody, im:7148342 antibody, wu:fc83h02 antibody, zgc:171230 antibody, SUMO1/sentrin specific peptidase 6 antibody, SUMO/sentrin specific peptidase 6 antibody, SUMO1/sentrin specific peptidase 6a antibody, SENP6 antibody, Senp6 antibody, senp6a antibody
    Background
    SENP6 is a UBL-specific protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. It does not seem to be involved in the processing of full-length SUMO proteins to their mature forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1, MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA, MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM].
    Alias Symbols: FLJ11355, FLJ11887, KIAA0389, KIAA0797, SSP1, SUSP1
    Protein Interaction Partner: UBC, SP1, LMNA, COPS5, SUMO2, KAT5, SUMO1, PLA2G2A, RUVBL2, ARNT,
    Protein Size: 1105
    Molecular Weight
    125 kDa
    Gene ID
    26054
    NCBI Accession
    NM_001100409, NP_001093879
    UniProt
    Q9GZR1
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