PHF6 antibody (PHD Finger Protein 6) (N-Term)

Details for Product anti-PHF6 Antibody No. ABIN2784476, Supplier: Log in to see
Antigen
  • zgc:55403
  • wu:fa22g03
  • BFLS
  • BORJ
  • CENP-31
  • 2700007B13Rik
  • 4931428F02Rik
  • mKIAA1823
  • PHD finger protein 6
  • phf6
  • PHF6
  • LOC100225613
  • LOC100346149
  • Phf6
Epitope
N-Term
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
40
18
8
8
6
4
4
3
3
2
1
1
Host
Rabbit
39
2
Clonality
Polyclonal
Conjugate
This PHF6 antibody is un-conjugated
1
1
1
Application
Western Blotting (WB)
36
14
12
8
7
6
5
Options
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PHF6
Sequence VGQNHSEDGA PALLTTAPPP GLQPGAGGTP GGPGGGGAPP RYATLEHPFH
Predicted Reactivity Cow: 93%, Dog: 100%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 100%
Characteristics This is a rabbit polyclonal antibody against PHF6. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name PHF6 (PHF6 Antibody Abstract)
Background PHF6 is a member of the plant homeodomain (PHD)-like finger (PHF) family. PHF6 is a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation that localizes to the nucleolus. Mutations affecting the coding region of its gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears.This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: BORJ, MGC14797, BFLS, CENP-31
Protein Interaction Partner: UBC, SUMO1, NEDD8, BMI1, HECW2, CAND1, CUL3, HDGF,
Protein Size: 365
Molecular Weight 41 kDa
Gene ID 84295
NCBI Accession NM_032458, NP_115834
UniProt Q8IWS0
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 365 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-PHD Finger Protein 6 (PHF6) (N-Term) antibody (ABIN2784476) WB Suggested Anti-PHF6 Antibody Titration: 5.0ug/ml
Positive Control:
Background publications Vallée, Chevrier, Graham, Lazzaro, Lavigne, Hunter, Picketts: "A novel PHF6 mutation results in enhanced exon skipping and mild Börjeson-Forssman-Lehmann syndrome." in: Journal of medical genetics, Vol. 41, Issue 10, pp. 778-83, 2004 (PubMed).

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