PHC2 antibody (N-Term)

Catalog No. ABIN2784482

Product Details anti-PHC2 Antibody

Target: PHC2 (PhC2) (Polyhomeotic Homolog 2 (Drosophila) (PhC2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHC2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GGSGRPTGPQ ISVYSGIPDR QTVQVIQQAL HRQPSTAAQY LQQMYAAQQQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against PHC2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PHC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 858 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PHC2

Target: PHC2 (PhC2) (Polyhomeotic Homolog 2 (Drosophila) (PhC2))

Alternative Name: PHC2 (PhC2 Products)

Background: In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: EDR2, HPH2, MGC163502, PH2
Protein Interaction Partner: FAM74A4, FAM74A1, FAM13C, FAM124A, MAGEB6, ZMAT2, ZNF417, MAB21L3, SSX2IP, TRIM41, ZGPAT, L3MBTL3, PCGF5, SPATC1L, FAM161A, ENKD1, KBTBD7, SYT16, THAP7, AEN, CARD9, CBX8, C1orf109, SFMBT1, PRPF31, PPP1R16B, KAT5, PCGF3, RWDD2B, ZBTB24, MORF4L2, RBM39, AP1
Protein Size: 858

Molecular Weight: 91 kDa

Gene ID: 1912

NCBI Accession: NM_198040, NP_932157

UniProt: Q8IXK0