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CBX2 antibody (N-Term)

CBX2 Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2784551
  • Target See all CBX2 Antibodies
    CBX2 (Chromobox Homolog 2 (CBX2))
    Binding Specificity
    • 10
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 60
    • 21
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig, Rabbit
    Host
    • 53
    • 6
    • 1
    Rabbit
    Clonality
    • 51
    • 8
    • 1
    Polyclonal
    Conjugate
    • 28
    • 6
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CBX2 antibody is un-conjugated
    Application
    • 42
    • 39
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    SSSSSSSTSS SSSSDEEDDS DLDAKRGPRG RETHPVPQKK AQILVAKPEL
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against CBX2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human CBX2
    Top Product
    Discover our top product CBX2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 532 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CBX2 (Chromobox Homolog 2 (CBX2))
    Alternative Name
    CBX2 (CBX2 Products)
    Synonyms
    cbx2 antibody, M33 antibody, pc1 antibody, wu:fd20e09 antibody, zgc:103563 antibody, MOD2 antibody, pc antibody, CDCA6 antibody, SRXY5 antibody, cdca6 antibody, m33 antibody, chromobox 2 antibody, chromobox homolog 2 (Drosophila Pc class) antibody, chromobox 2 L homeolog antibody, cbx2 antibody, CBX2 antibody, Cbx2 antibody, cbx2.L antibody
    Background
    CBX2 Contains 1 A.T hook DNA-binding domain and 1 chromo domain. CBX2 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
    Alias Symbols: CDCA6, M33, MGC10561, SRXY5
    Protein Interaction Partner: KRTAP10-3, KRTAP10-1, KRTAP10-9, KRTAP10-7, RBMY1F, DHX57, KRTAP2-4, RBMY1A1, RNF2, BMI1, MDFI, SOX2, GTF2I, PHC2, CSNK2B, CSNK2A2, CSNK2A1, CENPE, PARP1, CCDC158, DIS3L2, HIST4H4, CBX2, PARP12, RNF213, ZKSCAN7, DCAF6, KDM3A, MYCBP2, ANKRD26, PSME3, TRANK
    Protein Size: 532
    Molecular Weight
    56 kDa
    Gene ID
    84733
    NCBI Accession
    NM_005189, NP_005180
    UniProt
    Q14781
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