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ABAT antibody (Middle Region)

ABAT Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2784614
  • Target See all ABAT Antibodies
    ABAT (4-Aminobutyrate Aminotransferase (ABAT))
    Binding Specificity
    • 15
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 39
    • 25
    • 24
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit
    Host
    • 35
    • 5
    Rabbit
    Clonality
    • 34
    • 6
    Polyclonal
    Conjugate
    • 26
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ABAT antibody is un-conjugated
    Application
    • 39
    • 14
    • 13
    • 13
    • 10
    • 8
    • 5
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    YRSKERGQRG FSQEELETCM INQAPGCPDY SILSFMGAFH GRTMGCLATT
    Predicted Reactivity
    Cow: 93%, Dog: 86%, Goat: 77%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against ABAT. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human ABAT
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    Discover our top product ABAT Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 500 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    ABAT (4-Aminobutyrate Aminotransferase (ABAT))
    Alternative Name
    ABAT (ABAT Products)
    Synonyms
    cb880 antibody, fj82a01 antibody, wu:fj82a01 antibody, BA0325 antibody, PSPTO0259 antibody, PSPTO0301 antibody, PSPTO1890 antibody, GABA-AT antibody, GABAT antibody, NPD009 antibody, GABA-T antibody, L-AIBAT antibody, 9630038C02Rik antibody, AI255750 antibody, ENSMUSG00000051226 antibody, Gabaat antibody, Gabat antibody, Gm9851 antibody, I54 antibody, Laibat antibody, X61497 antibody, beta-AlaAT antibody, 4-aminobutyrate aminotransferase antibody, 4-aminobutyrate--2-oxoglutarate transaminase antibody, GABA aminotransferase PLP-dependent PuuE antibody, 4-aminobutyrate aminotransferase, mitochondrial antibody, aspartate aminotransferase family protein antibody, 4-aminobutyrate aminotransferase S homeolog antibody, ABAT antibody, abat antibody, gabT antibody, puuE antibody, gabT-1 antibody, gabT-2 antibody, gabT-3 antibody, CNE01830 antibody, Mmwyl1_0047 antibody, CpipJ_CPIJ008729 antibody, KCR_RS04555 antibody, Bcenmc03_4909 antibody, Hden_0972 antibody, Dbac_2000 antibody, Mesil_2400 antibody, Trad_0121 antibody, abat.S antibody, Abat antibody
    Background
    4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95 % similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
    Alias Symbols: GABA-AT, GABAT, NPD009
    Protein Interaction Partner: LGR4, BAG3, ALDH5A1, ABAT,
    Protein Size: 500
    Molecular Weight
    56 kDa
    Gene ID
    18
    NCBI Accession
    NM_020686, NP_065737
    UniProt
    P80404
    Pathways
    Monocarboxylic Acid Catabolic Process
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