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CENPB antibody (C-Term)

CENPB Reactivity: Human, Mouse, Rat, Horse, Pig, Sheep, Cow, Saccharomyces cerevisiae, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2784717
  • Target See all CENPB Antibodies
    CENPB (Centromere Protein B (CENPB))
    Binding Specificity
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    Human, Mouse, Rat, Horse, Pig, Sheep, Cow, Saccharomyces cerevisiae, Zebrafish (Danio rerio)
    Host
    • 16
    • 2
    Rabbit
    Clonality
    • 18
    Polyclonal
    Conjugate
    • 10
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This CENPB antibody is un-conjugated
    Application
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    GGEDSDSDSE EEDDEEEDDE DEDDDDDEED GDEVPVPSFG EAMAYFAMVK
    Predicted Reactivity
    Cow: 83%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 86%, Rat: 100%, Sheep: 86%, Yeast: 100%, Zebrafish: 75%
    Characteristics
    This is a rabbit polyclonal antibody against CENPB. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human CENPB
    Top Product
    Discover our top product CENPB Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 599 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CENPB (Centromere Protein B (CENPB))
    Alternative Name
    CENPB (CENPB Products)
    Synonyms
    CENPB antibody, CENP-B antibody, centromere protein B antibody, centromere protein B, 80kDa antibody, CENPB antibody, Cenpb antibody
    Background
    CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: -
    Protein Interaction Partner: UBC, RNF2, NR3C1, FBXO25, CENPA, APP, GFI1B, SUMO2, SMN1, PIN1, GSK3B, GADD45A, CSNK2B, CDKN1A, ANXA7, RPS6KA6, TK1, TAC1, TAF1D, PARP1, PARP2, HAND2, CENPB,
    Protein Size: 599
    Molecular Weight
    65 kDa
    Gene ID
    1059
    NCBI Accession
    NM_001810, NP_001801
    UniProt
    P07199
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