ADRBK2 antibody (N-Term)

Catalog No. ABIN2784754

Product Details anti-ADRBK2 Antibody

Target: ADRBK2 (Adrenergic, Beta, Receptor Kinase 2 (ADRBK2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Dog, Horse, Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRBK2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FCLNEINEAV PQVKFYEEIK EYEKLDNEED RLCRSRQIYD AYIMKELLSC

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 100%, Rat: 100%, Yeast: 80%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against ADRBK2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ADRBK2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 688 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ADRBK2

Target: ADRBK2 (Adrenergic, Beta, Receptor Kinase 2 (ADRBK2))

Alternative Name: ADRBK2 (ADRBK2 Products)

Synonyms: bark2 antibody, grk3 antibody, 4833444A01Rik antibody, AI851927 antibody, AW551196 antibody, Adrbk-2 antibody, Bark-2 antibody, GRK3 antibody, BARK2 antibody, Grk3 antibody, si:dz221d18.1 antibody, G protein-coupled receptor kinase 3 antibody, GRK3 antibody, grk3 antibody, Grk3 antibody

Background: ADRBK2 specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85 % amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95 % similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and ESTs. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-68 BC036797.1 1-68 69-124 BX387339.2 114-169 125-1307 BC036797.1 69-1251 1308-2783 BC036797.1 1402-2877 2784-7732 AL022329.9 173762-178710 7733-9068 BC063545.1 1-1336
Alias Symbols: BARK2, GRK3
Protein Interaction Partner: UBC, ADRBK1, MYC, GIT1, CCR4, CCR5, OPRM1, CXCR4, BDKRB2, AGTR1,
Protein Size: 688

Molecular Weight: 80 kDa

Gene ID: 157

NCBI Accession: NM_005160, NP_005151

UniProt: P35626

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling