RALBP1 antibody (N-Term)

Catalog No. ABIN2784844

Product Details anti-RALBP1 Antibody

Target: RALBP1 (RalA Binding Protein 1 (RALBP1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Horse, Pig, Rabbit, Cow, Goat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RALBP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MTECFLPPTS SPSEHRRVEH GSGLTRTPSS EEISPTKFPG LYRTGEPSPP

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 86%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against RALBP1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RALBP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 655 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RALBP1

Target: RALBP1 (RalA Binding Protein 1 (RALBP1))

Alternative Name: RALBP1 (RALBP1 Products)

Background: RALBP1 can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. RALBP1 mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes.RALBP1 can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. RALBP1 serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
Alias Symbols: RIP, RIP1, RLIP76, RLIP1
Protein Interaction Partner: TNIP1, CEP57, SMARCE1, PPL, GPS2, GSE1, ZNF707, ZBTB38, C1orf216, TBRG1, AMOTL2, TFPT, UBC, RALB, GPSM1, PRKCA, CPSF2, POLR2A, AP2A1, SYNJ2BP, HOOK2, REPS1, FADD, RAC1, TRAF2, CASP8, AP2M1, REPS2, IKBKG, RALA, CCNB1, HSP90AA1, HSF1, EPN1, NUMB, GTF3A, TNF
Protein Size: 655

Molecular Weight: 76 kDa

Gene ID: 10928

NCBI Accession: NM_006788, NP_006779

UniProt: Q15311