GRPEL2 antibody (Middle Region)

Catalog No. ABIN2785166

Product Details anti-GRPEL2 Antibody

Target: GRPEL2 (GrpE-Like 2, Mitochondrial (GRPEL2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRPEL2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: HEHELICHVP AGVGVQPGTV ALVRQDGYKL HGRTIRLARV EVAVESQRRL

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against GRPEL2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GRPEL2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 225 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GRPEL2

Target: GRPEL2 (GrpE-Like 2, Mitochondrial (GRPEL2))

Alternative Name: GRPEL2 (GRPEL2 Products)

Synonyms: mt-GrpE2 antibody, mt-Grpel2 antibody, Afap1l1 antibody, Mt-GrpE2 antibody, GrpE-like 2, mitochondrial antibody, GrpE like 2, mitochondrial antibody, Grpel2 antibody, GRPEL2 antibody

Background: GRPEL2 is an essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. GRPEL2 seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. GRPEL2 stimulates ATPase activity of mt-HSP70. GRPEL2 may also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70.
Alias Symbols: DKFZp451C205, FLJ23713, FLJ33918, Mt-GrpE#2
Protein Interaction Partner: ELAVL1, UBC, HSPA4,
Protein Size: 225

Molecular Weight: 25 kDa

Gene ID: 134266

NCBI Accession: NM_152407, NP_689620

UniProt: Q8TAA5