TMPRSS6 antibody (N-Term)

Catalog No. ABIN2785278

Product Details anti-TMPRSS6 Antibody

Target: TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMPRSS6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: LLWYFLGYKA EVMVSQVYSG SLRVLNRHFS QDLTRRESSA FRSETAKAQK

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TMPRSS6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TMPRSS6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 811 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TMPRSS6

Target: TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))

Alternative Name: TMPRSS6 (TMPRSS6 Products)

Synonyms: IRIDA antibody, 1300008A22Rik antibody, transmembrane protease, serine 6 antibody, transmembrane serine protease 6 antibody, Tmprss6 antibody, TMPRSS6 antibody

Background: TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter.The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
Alias Symbols: IRIDA
Protein Interaction Partner: LAMA1, FN1, COL1A1,
Protein Size: 811

Molecular Weight: 90 kDa

Gene ID: 164656

NCBI Accession: NM_153609, NP_705837

UniProt: Q8IU80

Pathways: Transition Metal Ion Homeostasis