HSD17B3 antibody (N-Term)

Catalog No. ABIN2785439

Product Details anti-HSD17B3 Antibody

Target: HSD17B3 (Hydroxysteroid (17-Beta) Dehydrogenase 3 (HSD17B3))

Binding Specificity: N-Term

Reactivity: Human, Rat, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AVITGAGDGI GKAYSFELAK RGLNVVLISR TLEKLEAIAT EIERTTGRSV

Predicted Reactivity: Horse: 79%, Human: 100%, Rat: 91%

Characteristics: This is a rabbit polyclonal antibody against HSD17B3. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 310 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HSD17B3 antibody (ABIN2785439)

Bertin, Dury, Ouellet, Pelletier, Labrie: "Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction." in: The journal of sexual medicine, Vol. 11, Issue 8, pp. 1949-61, (2014) (PubMed).

Target Details for HSD17B3

Target: HSD17B3 (Hydroxysteroid (17-Beta) Dehydrogenase 3 (HSD17B3))

Alternative Name: HSD17B3 (HSD17B3 Products)

Synonyms: EDH17B3 antibody, SDR12C2 antibody, hydroxysteroid (17-beta) dehydrogenase 3 antibody, hydroxysteroid 17-beta dehydrogenase 3 antibody, Hsd17b3 antibody, HSD17B3 antibody

Background: This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
Alias Symbols: EDH17B3, SDR12C2
Protein Size: 310

Molecular Weight: 34 kDa

Gene ID: 3293

NCBI Accession: NM_000197, NP_000188

UniProt: P37058

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis