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FUCA1 antibody (N-Term)

FUCA1 Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2785639
  • Target See all FUCA1 Antibodies
    FUCA1 (Fucosidase, alpha-L- 1, Tissue (FUCA1))
    Binding Specificity
    • 15
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 29
    • 28
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse, Pig
    Host
    • 52
    • 6
    • 1
    Rabbit
    Clonality
    • 55
    • 4
    Polyclonal
    Conjugate
    • 28
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This FUCA1 antibody is un-conjugated
    Application
    • 44
    • 21
    • 13
    • 13
    • 12
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB)
    Sequence
    PSPVSWNWNS KDVGPHRDLV GELGTALRKR NIRYGLYHSL LEWFHPLYLL
    Predicted Reactivity
    Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 79%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against FUCA1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human FUCA1
    Top Product
    Discover our top product FUCA1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 466 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    FUCA1 (Fucosidase, alpha-L- 1, Tissue (FUCA1))
    Alternative Name
    FUCA1 (FUCA1 Products)
    Synonyms
    FUCA antibody, FUCA1 antibody, 0610006A03Rik antibody, 9530055J05Rik antibody, Afuc antibody, Fuca antibody, fuca antibody, fuca1 antibody, ATFUC1 antibody, F24D13.11 antibody, F24D13_11 antibody, alpha-L-fucosidase 1 antibody, wu:fb02a09 antibody, zgc:101116 antibody, alpha-L-fucosidase 1 antibody, fucosidase, alpha-L- 1, tissue antibody, alpha-L-fucosidase 1 L homeolog antibody, alpha-L-fucosidase 1, tandem duplicate 2 antibody, FUCA1 antibody, Fuca1 antibody, fuca1.L antibody, fuca1 antibody, FUC1 antibody, LOC9317020 antibody, LOC100285202 antibody, fuca1.2 antibody
    Background
    Alpha-L-fucosidase (EC 3.2.1.51) is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. At least 2 separate polymorphic alpha-L-fucosidases are recognized in man: that in tissues, FUCA1, which is deficient in fucosidosis, and that in plasma, FUCA2. Fucosidosis is an autosomal recessive lysosomal storage disease caused by defective alpha-L-fucosidase with accumulation of fucose in the tissues. Different phenotypes include clinical features such as neurologic deterioration, growth retardation, visceromegaly, and seizures in a severe early form, coarse facial features, angiokeratoma corporis diffusum, spasticity and delayed psychomotor development in a longer surviving form, and an unusual spondylometaphyseoepiphyseal dysplasia in yet another form.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: FUCA
    Protein Interaction Partner: PAXIP1, BARD1, APP, CUL3, VAV2, USP21, MARK2,
    Protein Size: 466
    Molecular Weight
    54 kDa
    Gene ID
    2517
    NCBI Accession
    NM_000147, NP_000138
    UniProt
    P04066
    Pathways
    Glycosaminoglycan Metabolic Process
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