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Glutathione Reductase antibody (N-Term)

GSR Reactivity: Human, Rat, Mouse, Guinea Pig, Rabbit, Cow, Dog, Horse WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2785662
  • Target See all Glutathione Reductase (GSR) Antibodies
    Glutathione Reductase (GSR)
    Binding Specificity
    • 15
    • 15
    • 10
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 51
    • 19
    • 19
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Guinea Pig, Rabbit, Cow, Dog, Horse
    Host
    • 70
    • 7
    Rabbit
    Clonality
    • 70
    • 7
    Polyclonal
    Conjugate
    • 33
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Glutathione Reductase antibody is un-conjugated
    Application
    • 54
    • 30
    • 26
    • 26
    • 26
    • 21
    • 15
    • 12
    • 9
    • 9
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    PTIEVSGKKY TAPHILIATG GMPSTPHESQ IPGASLGITS DGFFQLEELP
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against GSR. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human GSR
    Top Product
    Discover our top product GSR Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 522 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Hoffmann, Dietrich, Herrmann, Schacht, Albrecht, Methner: "Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 6093903, (2017) (PubMed).

  • Target
    Glutathione Reductase (GSR)
    Alternative Name
    GSR (GSR Products)
    Synonyms
    GR antibody, ATGR2 antibody, EMB2360 antibody, glutathione reductase antibody, AI325518 antibody, D8Ertd238e antibody, Gr-1 antibody, Gr1 antibody, DDBDRAFT_0168952 antibody, DDBDRAFT_0231410 antibody, DDB_0168952 antibody, DDB_0231410 antibody, 2151 antibody, CG2151 antibody, DTR antibody, Dm-TrxR antibody, DmTR antibody, DmTrx antibody, DmTrxR antibody, DmTrxR-1 antibody, Dmel\\CG2151 antibody, Gr antibody, Trx antibody, TrxR antibody, TrxR-1 antibody, Trxr1 antibody, anon-WO03040301.185 antibody, anon-WO03040301.187 antibody, dTrxR antibody, dmtrxr-1 antibody, gr antibody, l(1)G0154 antibody, l(1)G0379 antibody, l(1)G0477 antibody, l(1)G0481 antibody, trxr-1 antibody, gor1 antibody, glutathione reductase, gro-2 antibody, glutathione reductase antibody, glutathione-disulfide reductase antibody, GR; GRase antibody, mitochondrial glutathione reductase Pgr1 antibody, Glutathione reductase (GR) (GRase) antibody, Thioredoxin reductase-1 antibody, glutathione-disulfide reductase family protein antibody, glutathione reductase 1 antibody, GR antibody, gor antibody, GSR antibody, GSR1 antibody, Gsr_2 antibody, Gsr antibody, GSHR1 antibody, gsr antibody, LbGR antibody, pgr1 antibody, GSHR2 antibody, GLR2 antibody, Bcen_2392 antibody, RPE_1989 antibody, HCAG_02219 antibody, SJAG_01162 antibody, Trxr-1 antibody, PF14_0192 antibody, POPTR_0001s14480g antibody, gsr1 antibody
    Background
    GSR belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. It maintains high levels of reduced glutathione in the cytosol. Both glutathione and glutathione reductase are inducible by D3T, and that upregulation of GSH biosynthesis underlies D3T-mediated cytoprotection against ROS/RNS-elicited injury to human vascular smooth muscle cells.
    Alias Symbols: MGC78522
    Protein Interaction Partner: SUMO1, CNDP2, GINS2, PROSC, AHSA1, NDRG1, DDX39A, NAMPT, KYNU, DDX39B, RPS6KA1, PEPD, MVD, LDHA, HSPD1, GBP2, EEF2, ADSS, C11orf49, UBC, FOLR1, ISG15, ELAVL1, SUMO4, PJA1, OCM, GSR,
    Protein Size: 522
    Molecular Weight
    56 kDa
    Gene ID
    2936
    NCBI Accession
    NM_000637, NP_000628
    UniProt
    P00390
    Pathways
    Thyroid Hormone Synthesis, Cell RedoxHomeostasis
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