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NARF antibody (Middle Region)

NARF Reactivity: Human, Mouse, Rat, Rabbit, Horse, Cow, Dog, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2785739
  • Target See all NARF Antibodies
    NARF (Nuclear Prelamin A Recognition Factor (NARF))
    Binding Specificity
    • 16
    • 7
    • 7
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    Human, Mouse, Rat, Rabbit, Horse, Cow, Dog, Guinea Pig
    Host
    • 50
    • 1
    Rabbit
    Clonality
    • 50
    • 1
    Polyclonal
    Conjugate
    • 17
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This NARF antibody is un-conjugated
    Application
    • 39
    • 27
    • 13
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    FRNIQNMILK LKKGKFPFHF VEVLACAGGC LNGRGQAQTP DGHADKALLR
    Predicted Reactivity
    Cow: 92%, Dog: 86%, Guinea Pig: 92%, Horse: 86%, Human: 100%, Mouse: 92%, Rabbit: 79%, Rat: 92%
    Characteristics
    This is a rabbit polyclonal antibody against NARF. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human NARF
    Top Product
    Discover our top product NARF Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 502 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    NARF (Nuclear Prelamin A Recognition Factor (NARF))
    Alternative Name
    NARF (NARF Products)
    Synonyms
    NARF antibody, IOP2 antibody, 4430402O11Rik antibody, RGD1310894 antibody, wu:fa03c01 antibody, zgc:92186 antibody, nuclear prelamin A recognition factor antibody, nuclear prelamin A recognition factor L homeolog antibody, NARF antibody, NAEGRDRAFT_78871 antibody, VDBG_04882 antibody, Tsp_07547 antibody, Tsp_07549 antibody, Narf antibody, narf antibody, narf.L antibody
    Background
    Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. NARF binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. NARF is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases.Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.
    Alias Symbols: DKFZp434G0420, FLJ10067, IOP2
    Protein Interaction Partner: UBC, LEF1, STAT5A, SHFM1, MMS19, CBX5, APP, LMNA,
    Protein Size: 502
    Molecular Weight
    55 kDa
    Gene ID
    26502
    NCBI Accession
    NM_031968, NP_114174
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