Granulin antibody (Middle Region)

Catalog No. ABIN2785816

Product Details anti-Granulin Antibody

Target: Granulin (GRN)

Binding Specificity: Middle Region

Reactivity: Human, Horse, Cow, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Granulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: CPMPNATCCS DHLHCCPQDT VCDLIQSKCL SKENATTDLL TKLPAHTVGD

Predicted Reactivity: Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Rabbit: 85%

Characteristics: This is a rabbit polyclonal antibody against GRN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human GRN

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Granulin

Target: Granulin (GRN)

Alternative Name: GRN (GRN Products)

Synonyms: GRN antibody, grn antibody, wu:fb11g12 antibody, wu:fj18f05 antibody, MGC53354 antibody, DKFZp459H066 antibody, CLN11 antibody, GEP antibody, GP88 antibody, PCDGF antibody, PEPI antibody, PGRN antibody, epithelin antibody, acrogranin antibody, granulin precursor antibody, granulin a antibody, Granulins antibody, granulin L homeolog antibody, granulin antibody, GRN antibody, grna antibody, grn antibody, grn.L antibody, granulin antibody, ORF1 granulin antibody, Grn antibody

Target Type: Viral Protein

Background: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Alias Symbols: CLN11, GEP, GP88, PCDGF, PEPI, PGRN
Protein Interaction Partner: OTX1, HOXA1, DLX2, SGTA, KRTAP26-1, KRTAP10-7, CCDC33, ARFGAP1, FANCL, NLK, GLRX3, EED, HECW2, Hk3, RPS6KA1, NPM1, POT1, FRAT1, YY1, TGM2, RAC1, PRKAB2, PIK3R2, SMAD9, KRT18, CRY1, CFTR, CCNG1, FBXO6, GFI1B, ATN1, CDK2, CRKL, VHL, SIRT3, ATXN7, CACNA1A, C
Protein Size: 438

Molecular Weight: 48 kDa

Gene ID: 2896

NCBI Accession: NM_002087, NP_002078