GTPBP4 antibody (C-Term)

Catalog No. ABIN2785935

Product Details anti-GTPBP4 Antibody

Target: GTPBP4 (GTP Binding Protein 4 (GTPBP4))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTPBP4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MVKKAKTMMK NAQKKMNRLG KKGEADRHVF DMKPKHLLSG KRKAGKKDRR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GTPBP4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human GTPBP4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 634 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GTPBP4

Target: GTPBP4 (GTP Binding Protein 4 (GTPBP4))

Alternative Name: GTPBP4 (GTPBP4 Products)

Synonyms: CRFG antibody, NGB antibody, NOG1 antibody, 2610028C09Rik antibody, Crfg antibody, Gtpbp3 antibody, Nog1 antibody, fi28d07 antibody, zgc:55757 antibody, wu:fi28d07 antibody, xgb antibody, GTP binding protein 4 antibody, GTP binding protein 4 L homeolog antibody, GTPBP4 antibody, Gtpbp4 antibody, gtpbp4 antibody, CC1G_14285 antibody, gtpbp4.L antibody

Background: GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
Alias Symbols: CRFG, FLJ10686, FLJ10690, FLJ39774, NGB, NOG1
Protein Interaction Partner: SUMO3, UBC, POP1, PNMA2, PSME3, PRKRA, SUMO1, STAU1, NEDD8, EIF6, IFRD1, AZGP1, MRTO4, KCTD2, DICER1, SUZ12, EED, RNF2, CSNK2A2, CBX8, VCAM1, FN1, ESR1, UBD, CAND1, COPS5, SIRT7, SUMO2, EIF2AK2, OAS3, tat, TP53, YWHAG, LYAR, PINX1,
Protein Size: 634

Molecular Weight: 74 kDa

Gene ID: 23560

NCBI Accession: NM_012341, NP_036473

UniProt: Q9BZE4