POLL antibody (Middle Region)

Catalog No. ABIN2785955

Product Details anti-POLL Antibody

Target: POLL (Polymerase (DNA Directed), lambda (POLL))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Rabbit, Cow, Guinea Pig, Dog, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLL antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SLSEHALSTA VVRNTHGCKV GPGRVLPTPT EKDVFRLLGL PYREPAERDW

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 93%, Yeast: 83%

Characteristics: This is a rabbit polyclonal antibody against POLL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human POLL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 575 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for POLL

Target: POLL (Polymerase (DNA Directed), lambda (POLL))

Alternative Name: POLL (POLL Products)

Synonyms: T10O24.13 antibody, T10O24_13 antibody, zgc:66320 antibody, zgc:77901 antibody, wu:fe49a04 antibody, beta-n antibody, pol-kappa antibody, BETAN antibody, POLKAPPA antibody, 1110003P06Rik antibody, AV007317 antibody, DNA polymerase lambda (POLL) antibody, DNA polymerase lambda antibody, polymerase (DNA directed), lambda antibody, polymerase (DNA) lambda antibody, Pol{lambda} antibody, PTRG_00468 antibody, poll antibody, POLL antibody, MCYG_03796 antibody, LOC9325878 antibody, MGYG_02138 antibody, Poll antibody

Background: POLL is a repair polymerase.It is involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Alias Symbols: BETA-N, FLJ46002, POL-KAPPA, BETAN, POLKAPPA
Protein Interaction Partner: KRTAP10-3, KRTAP10-7, FAM9B, KRT40, FSD2, SSX2IP, TFIP11, PNMA1, TFCP2, MAGEA12, TRIM23, APP, DCUN1D1, REV1, LDOC1, RPA1, PCNA, CDK2, UBE2H, UBE2E1, UBE2D3, UBE2D2, UBE2D1,
Protein Size: 575

Molecular Weight: 63 kDa

Gene ID: 27343

NCBI Accession: NM_013274, NP_037406

UniProt: Q9UGP5

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response